Myo1 appears to be crucial for maintaining the blastodisc morphology and the actin cortex thickness. We found that the blastodisc of the embryo, which contains a thick actin cortex (~13 μm), is loaded with cortical Myo1. While Myo1 isoforms appears to be important for both the formation and the maintenance of cleavage furrows, Myo2 is required only for the formation of furrows. ![]() Inhibition of Myo1 (by PClP) and Myo2 (by Blebbistatin) lead to arrest in cell division. Our results indicate a unique involvement of Myo1 in early development of Zebrafish embryos. ![]() We have studied the effect of Myo1 inhibitor PClP in 1–8 cell Zebrafish embryos. Myosin-1 (Myo1) represents a mechanical link between the membrane and actin-cytoskeleton in animal cells.
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